PPARα-dependent increase of mouse urine output by gemfibrozil and fenofibrate
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PPARα-dependent increase of mouse urine output by gemfibrozil and fenofibrate.
While gemfibrozil and fenofibrate are prescribed for anti-dyslipidemia treatment, a rational basis for the use of these drugs for treatment of dyslipidemia with concurrent metabolic syndrome has not been established. In this study, wild-type and Pparα-null mice were fed gemfibrozil- or fenofibrate-containing diets for 14 days. Urine output (24 h) was monitored, and urine, serum, and liver and k...
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Fibrates, such as fenofibrate, are peroxisome proliferator-activated receptor-α (PPARα) agonists and have been used for several decades as hypolipidemic agents in the clinic. However, contradictory observations exist on the role of fibrates in host response to acute inflammation, with unclear mechanisms. The role of PPARα in colitis was assessed using fenofibrate and Ppara-null mice. Wild-type ...
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Oligodendrocytes are major myelin-producing cells and play essential roles in the function of a healthy nervous system. However, they are also one of the most vulnerable neural cell types in the central nervous system (CNS), and myelin abnormalities in the CNS are found in a wide variety of neurological disorders, including multiple sclerosis, adrenoleukodystrophy, and schizophrenia. There is a...
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Gemfibrozil coadministration generally results in plasma statin area under the curve (AUC) increases, ranging from moderate (2- to 3-fold) with simvastatin, lovastatin, and pravastatin to most significant with cerivastatin (5.6-fold). Inhibition of statin glucuronidation has been postulated as a potential mechanism of interaction (Drug Metab Dispos 30:1280-1287, 2002). This study was conducted ...
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Peroxisome proliferator-activated receptor α (PPARα) is highly expressed in heart, but its metabolic regulation effect in rats with myocardial ischemia/reperfusion injury is still a controversy. In this study, the cardioprotective effect of PPARα activation in rats with myocardial ischemia/reperfusion injury and its relevant mechanism was investigated. Adult male Wistar rats were pretreated wit...
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ژورنال
عنوان ژورنال: Canadian Journal of Physiology and Pharmacology
سال: 2017
ISSN: 0008-4212,1205-7541
DOI: 10.1139/cjpp-2016-0140